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After decades of development, flow-based microfluidic biochips have become an increasingly attractive platform for biochemical experiments. The fluid transportation and the on-chip device operation are controlled by microvalves, which are driven by external pneumatic controllers. To meet the increasingly complex experimental demands, the number of microvalves has significantly increased, making it necessary to adopt multiplexers (MUXes) for the actuation of microvalves. However, existing MUX designs have limited coding capacities, resulting in area overhead and excessive chip-to-world interface. This paper proposes a novel gate structure for modifying the current MUX architecture, along with a mixed coding strategy that achieves the maximum coding capacity within the modified MUX architecture. Additionally, an efficient synthesis tool for the mixed-coding-based MUXes (LaMUXes) is presented. Experimental results demonstrate that the LaMUX is exceptionally efficient, substantially reducing the usage of pneumatic controllers and microvalves compared to existing MUX designs. 

Temporal isolation is one of the most significant challenges that must be addressed before Multi-Processor Systems-on-Chip (MPSoCs) can be widely adopted in mixed-criticality systems with both time-sensitive real-time (RT) applications and performance-oriented non-real-time (NRT) applications. Specifically, the main memory subsystem is one of the most prevalent causes of interference, performance degradation and loss of isolation. Existing memory bandwidth regulation mechanisms use static, dynamic, or predictive DRAM bandwidth management techniques to restore the execution time of an application under contention as close as possible to the execution time in isolation. In this paper, we propose a novel distribution-driven regulation whose goal is to achieve a timeliness objective formulated as a constraint on the probability of meeting a certain target execution time for the RT applications. Using existing interconnect-level Performance Monitoring Units (PMU), we can observe the Cumulative Distribution Function (CDF) of the per-request memory latency. Regulation is then triggered to enforce first-order stochastical dominance with respect to a desired reference. Consequently, it is possible to enforce that the overall observed execution time random variable is dominated by the reference execution time. The mechanism requires no prior information of the contending application and treats the DRAM subsystem as a black box. We provide a full-stack implementation of our mechanism on a Commercial Off-The-Shelf (COTS) platform (Xilinx Ultrascale+ MPSoC), evaluate it using real and synthetic benchmarks, experimentally validate that the timeliness objectives are met for the RT applications, and demonstrate that it is able to provide 2.2x more overall throughput for NRT applications compared to DRAM bandwidth management-based regulation approaches.